|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:DPC4
gptkb:MADH4
|
|
gptkbp:binds
|
gptkb:SMAD2
gptkb:SMAD3
gptkb:gene
|
|
gptkbp:discoveredBy
|
gptkb:Bert_Vogelstein
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
MH1 domain
MH2 domain
|
|
gptkbp:encodes
|
gptkb:Mothers_against_decapentaplegic_homolog_4
|
|
gptkbp:Entrez_Gene_ID
|
4089
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:function
|
signal transduction
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6770
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SMAD4
|
|
gptkbp:involvedIn
|
gptkb:BMP_signaling_pathway
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:length
|
552 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:18q21.2
gptkb:chromosome_18
|
|
gptkbp:memberOf
|
gptkb:SMAD_family
|
|
gptkbp:molecularWeight
|
60 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:juvenile_polyposis_syndrome
gptkb:hereditary_hemorrhagic_telangiectasia
colorectal cancer
pancreatic cancer
|
|
gptkbp:OMIM
|
600993
|
|
gptkbp:orthologIn
|
gptkb:Drosophila_melanogaster_(Medea)
Mus musculus (mouse)
|
|
gptkbp:pathway
|
KEGG: hsa04350 (TGF-beta signaling)
Reactome: R-HSA-170834 (Signaling by TGF-beta Receptor Complex)
|
|
gptkbp:PDB
|
gptkb:1U7V
3QSV
|
|
gptkbp:phosphorylates
|
Serine 465
Serine 467
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
gptkb:Ensembl
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q13485
|
|
gptkbp:bfsParent
|
gptkb:Osler-Weber-Rendu_disease
|
|
gptkbp:bfsLayer
|
5
|