Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
GRIP1
NRC2 SRC-2 TIF2 |
| gptkbp:alternativeSplicing |
produces multiple transcript variants
|
| gptkbp:associatedWith |
gptkb:endometrial_cancer
gptkb:mesenchymal_chondrosarcoma prostate cancer acute leukemia |
| gptkbp:biologicalProcess |
chromatin organization
regulation of transcription, DNA-templated transcription coactivator activity |
| gptkbp:cellularComponent |
nuclear chromatin
|
| gptkbp:chromosomeArm |
q
|
| gptkbp:discoveredIn |
1997
|
| gptkbp:encodes |
Nuclear receptor coactivator 2 protein
|
| gptkbp:Entrez_Gene_ID |
10499
ENSG00000124151 |
| gptkbp:fullName |
Nuclear receptor coactivator 2
|
| gptkbp:function |
mediates hormone-dependent transcriptional activation
involved in chromatin remodeling acts as a transcriptional coactivator for steroid and nuclear hormone receptors |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
7669
|
| https://www.w3.org/2000/01/rdf-schema#label |
NCOA2
|
| gptkbp:interactsWith |
gptkb:CREBBP
gptkb:EP300 gptkb:PPARG gptkb:NCOA1 gptkb:NCOA3 AR (androgen receptor) ESR1 (estrogen receptor alpha) NR3C1 (glucocorticoid receptor) |
| gptkbp:length |
1464
|
| gptkbp:locatedOnChromosome |
8
q13 |
| gptkbp:location_(GRCh38) |
8q13.3
|
| gptkbp:molecularWeight |
~155 kDa
|
| gptkbp:mutationAssociatedWith |
gene fusions with PAX3 in alveolar rhabdomyosarcoma
gene fusions with ETV6 in leukemia |
| gptkbp:OMIM |
601833
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
mouse Ncoa2
rat Ncoa2 |
| gptkbp:proteinFamily |
bHLH-PAS domain
AD1 domain AD2 domain LXXLL motif |
| gptkbp:subcellularLocation |
gptkb:nucleus
|
| gptkbp:UniProtID |
Q15596
|
| gptkbp:bfsParent |
gptkb:Androgen_receptor
|
| gptkbp:bfsLayer |
7
|