|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
DNA methyltransferase HsaIIIA
DNMT3
M.HsaIIIA
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
overgrowth syndrome
Tatton-Brown-Rahman syndrome
|
|
gptkbp:component
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
Okano et al.
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:domain
|
PWWP domain
ADD domain
MTase domain
|
|
gptkbp:encodes
|
DNA methyltransferase 3A protein
|
|
gptkbp:Entrez_Gene_ID
|
1788
ENSG00000119772
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
DNA (cytosine-5)-methyltransferase 3A
|
|
gptkbp:function
|
epigenetic regulation
DNA (cytosine-5)-methyltransferase activity
de novo DNA methylation
|
|
gptkbp:GOProcess
|
DNA methylation
|
|
gptkbp:HGNC_ID
|
2976
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNMT3A
|
|
gptkbp:interactsWith
|
gptkb:HDAC1
gptkb:DNMT3B
gptkb:DNMT3L
|
|
gptkbp:length
|
912 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2p23.3
|
|
gptkbp:molecularWeight
|
104 kDa
|
|
gptkbp:mutationAssociatedWith
|
nonsense
missense
frameshift
R882
|
|
gptkbp:OMIM
|
602769
|
|
gptkbp:orthologInMouse
|
Dnmt3a
|
|
gptkbp:proteinFamily
|
DNA methyltransferase family
|
|
gptkbp:relatedTo
|
gptkb:cancer
epigenetics
hematopoiesis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q9Y6K1
|
|
gptkbp:bfsParent
|
gptkb:DNMT3A_mutation
gptkb:DNA_methyltransferase
gptkb:SETDB1
gptkb:ORF73_(LANA)
|
|
gptkbp:bfsLayer
|
7
|