|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:androgen_insensitivity_syndrome
gptkb:spinal_and_bulbar_muscular_atrophy
prostate cancer
|
|
gptkbp:binds
|
gptkb:androgens
gptkb:dihydrotestosterone
testosterone
|
|
gptkbp:discoveredBy
|
gptkb:E._L._Simpson
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:domain
|
DNA-binding domain
N-terminal domain
ligand-binding domain
|
|
gptkbp:encodedBy
|
gptkb:AR_gene
|
|
gptkbp:enemyOf
|
gptkb:bicalutamide
gptkb:flutamide
gptkb:enzalutamide
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:prostate
gptkb:testis
brain
|
|
gptkbp:function
|
regulates gene expression
mediates effects of androgens
|
|
gptkbp:gene
|
AR
|
|
gptkbp:hasAgonist
|
gptkb:dihydrotestosterone
testosterone
|
|
gptkbp:HGNC_ID
|
HGNC:644
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
androgen receptor
|
|
gptkbp:ligand
|
gptkb:dihydrotestosterone
testosterone
|
|
gptkbp:locatedIn
|
cell nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xq11-12
|
|
gptkbp:memberOf
|
gptkb:steroid_hormone_receptor_family
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:androgen_insensitivity_syndrome
gptkb:spinal_and_bulbar_muscular_atrophy
|
|
gptkbp:OMIM
|
313700
|
|
gptkbp:orthologIn
|
gptkb:mouse_androgen_receptor
gptkb:rat_androgen_receptor
|
|
gptkbp:PDB
|
1I37
|
|
gptkbp:regulates
|
hair growth
male sexual development
muscle mass
|
|
gptkbp:target
|
gptkb:bicalutamide
gptkb:flutamide
gptkb:enzalutamide
antiandrogens
|
|
gptkbp:UniProtID
|
P10275
|
|
gptkbp:bfsParent
|
gptkb:Sertoli_cells
gptkb:androgens
|
|
gptkbp:bfsLayer
|
6
|