|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:catalyzes
|
gptkb:p110α
gptkb:p110γ
gptkb:p110δ
gptkb:p110β
|
|
gptkbp:discoveredBy
|
gptkb:Lewis_Cantley
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:EC_number
|
2.7.1.153
|
|
gptkbp:enzymeClassification
|
kinase
|
|
gptkbp:fullName
|
Phosphoinositide 3-kinase family
|
|
gptkbp:function
|
signal transduction
phosphorylation of phosphoinositides
|
|
gptkbp:GO_term
|
gptkb:GO:0016303
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K family
|
|
gptkbp:inhibitedBy
|
gptkb:Wortmannin
gptkb:LY294002
gptkb:Alpelisib
Copanlisib
Duvelisib
Idelalisib
Umbralisib
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:member
|
gptkb:PIK3R1
gptkb:PIK3R2
gptkb:PIK3R3
gptkb:PIK3R5
gptkb:PIK3R6
gptkb:PIK3R4
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
gptkb:yeast
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT_pathway
gptkb:mTOR_pathway
insulin signaling pathway
growth factor signaling
|
|
gptkbp:product
|
gptkb:phosphatidylinositol_3,4,5-trisphosphate
gptkb:phosphatidylinositol_3,4-bisphosphate
|
|
gptkbp:role
|
gptkb:cancer
gptkb:diabetes
inflammation
autoimmune disease
|
|
gptkbp:subfamily
|
gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
|
|
gptkbp:substrate
|
phosphatidylinositol
phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:subunit
|
gptkb:p55γ
gptkb:p85β
gptkb:p101
gptkb:p84
gptkb:p85α
|
|
gptkbp:UniProtID
|
gptkb:Signal_transduction
Lipid metabolism
|
|
gptkbp:bfsParent
|
gptkb:Class_IB_PI3K
|
|
gptkbp:bfsLayer
|
6
|