|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:PI3K_inhibitor
|
|
gptkbp:CASNumber
|
154447-36-6
|
|
gptkbp:chemicalClass
|
gptkb:chromones
gptkb:morpholines
|
|
gptkbp:hasApplication
|
apoptosis research
cancer research
cell signaling studies
|
|
gptkbp:hasMolecularFormula
|
C19H17NO3
|
|
gptkbp:hasSMILES
|
C1COCCN1C2=CC=CC=C2C3=CC=CC=C3O4
|
|
gptkbp:inhibitedBy
|
phosphoinositide 3-kinases
|
|
gptkbp:is_not_approved_for
|
clinical use
|
|
gptkbp:IUPACName
|
gptkb:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
|
|
gptkbp:mechanismOfAction
|
blocks PI3K/AKT signaling pathway
|
|
gptkbp:meltingPoint
|
215-217°C
|
|
gptkbp:molecularWeight
|
307.34 g/mol
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL958
3973
|
|
gptkbp:routeOfAdministration
|
in vitro
in vivo (animal studies)
|
|
gptkbp:sideEffect
|
off-target effects
cytotoxicity
|
|
gptkbp:synonym
|
gptkb:4H-1-Benzopyran-4-one,_2-(4-morpholinyl)-8-phenyl-
gptkb:PI3K_inhibitor_LY294002
|
|
gptkbp:target
|
gptkb:DNA-PK
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
gptkb:mTOR
|
|
gptkbp:used_in
|
biological research
|
|
gptkbp:bfsParent
|
gptkb:PI3K
|
|
gptkbp:bfsLayer
|
5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LY294002
|