Statements (37)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
gptkb:receptor_tyrosine_kinases
G-protein coupled receptors |
| gptkbp:alternativeName |
PI3K class II
phosphoinositide 3-kinase class II |
| gptkbp:catalyzes |
phosphorylation of phosphoinositides
|
| gptkbp:compatibleWith |
regulatory subunit
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
C2 domain
PI3K catalytic domain PI3K helical domain |
| gptkbp:encodedBy |
gptkb:PIK3C2A
gptkb:PIK3C2B gptkb:PIK3C2G |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:hasIsoform |
gptkb:PI3K-C2α
gptkb:PI3K-C2β gptkb:PI3K-C2γ |
| https://www.w3.org/2000/01/rdf-schema#label |
Class II PI3K
|
| gptkbp:involvedIn |
cell signaling
endocytosis membrane trafficking |
| gptkbp:molecularWeight |
~180 kDa
|
| gptkbp:phosphorylates |
phosphatidylinositol
phosphatidylinositol 4,5-bisphosphate phosphatidylinositol 4-phosphate |
| gptkbp:regulates |
vesicle trafficking
angiogenesis cell migration insulin signaling |
| gptkbp:subclassOf |
gptkb:PI3K
|
| gptkbp:substrate |
phosphatidylinositol
phosphatidylinositol 4,5-bisphosphate phosphatidylinositol 4-phosphate |
| gptkbp:bfsParent |
gptkb:protein
|
| gptkbp:bfsLayer |
4
|