Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
fungal metabolite PI3-kinase inhibitor |
| gptkbp:application |
used in cancer research
used in cell signaling research |
| gptkbp:biological_effect |
blocks PI3K/Akt signaling pathway
induces apoptosis in some cell types |
| gptkbp:CASNumber |
19545-26-7
|
| gptkbp:chemicalFormula |
C23H24O8
|
| gptkbp:hasSMILES |
COC1=C2C(=C(C(=O)C3=C(C2=O)C(=C(C(=C3OC)O)O)OC)O)C4C5C(C4O)C(C5O)O1
|
| https://www.w3.org/2000/01/rdf-schema#label |
Wortmannin
|
| gptkbp:IUPACName |
(1S,9R,10R,11S,15R,17S,18R,21R)-11,17,21-trihydroxy-10,15,18-trimethoxy-2,8,16,22-tetraoxapentacyclo[12.8.0.01,9.010,15.018,23]tricosa-3,6-diene-23,24-dione
|
| gptkbp:mechanismOfAction |
irreversible inhibitor of phosphoinositide 3-kinases (PI3Ks)
inhibits phosphatidylinositol 4-kinase (PI4K) |
| gptkbp:molecularWeight |
428.43 g/mol
|
| gptkbp:organism |
gptkb:Penicillium_wortmannii
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL418
3002415 |
| gptkbp:UNII |
1W8M12WXY3
|
| gptkbp:bfsParent |
gptkb:Class_III_PI3K
|
| gptkbp:bfsLayer |
5
|