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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
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gptkb:G_protein-coupled_receptors_(Class_IB)
gptkb:receptor_tyrosine_kinases_(Class_IA)
|
|
gptkbp:catalyzes
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phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2)
|
|
gptkbp:Class_IA_catalytic_subunit
|
gptkb:PIK3CA_(p110α)
gptkb:PIK3CB_(p110β)
PIK3CD (p110δ)
|
|
gptkbp:Class_IA_regulatory_subunit
|
gptkb:PIK3R2_(p85β)
gptkb:PIK3R3_(p55γ)
PIK3R1 (p85α, p55α, p50α)
|
|
gptkbp:Class_IB_catalytic_subunit
|
gptkb:PIK3CG_(p110γ)
|
|
gptkbp:Class_IB_regulatory_subunit
|
PIK3R5 (p101)
PIK3R6 (p87/p84)
|
|
gptkbp:discoveredBy
|
gptkb:Lewis_Cantley
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:gene
|
gptkb:PIK3R1
gptkb:PIK3R2
gptkb:PIK3R3
gptkb:PIK3R5
gptkb:PIK3R6
gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Class I PI3K
|
|
gptkbp:inhibitedBy
|
gptkb:LY294002
gptkb:wortmannin
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
immune cell function
|
|
gptkbp:involves
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
immunodeficiency
|
|
gptkbp:product
|
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
|
gptkbp:subclassOf
|
gptkb:Class_IA_PI3K
gptkb:Class_IB_PI3K
|
|
gptkbp:subunit
|
p110 catalytic subunit
regulatory subunit (p85, p55, or p50)
|
|
gptkbp:targetOfDrug
|
gptkb:alpelisib
gptkb:copanlisib
gptkb:duvelisib
gptkb:idelalisib
gptkb:umbraliciclib
|
|
gptkbp:bfsParent
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|