|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
small GTPases (e.g., Ras, Rap1)
|
|
gptkbp:alternativeName
|
gptkb:PLCE1
gptkb:Phospholipase_C-epsilon-1
|
|
gptkbp:associatedWith
|
gptkb:nephrotic_syndrome
gptkb:cancer
|
|
gptkbp:discoveredBy
|
gptkb:Kazusa_DNA_Research_Institute
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:domain
|
gptkb:PH_domain
gptkb:EF-hand_domain
C2 domain
CDC25 homology domain
Ras-associating domain
|
|
gptkbp:encodedBy
|
gptkb:PLCE1_gene
|
|
gptkbp:fullName
|
gptkb:Phospholipase_C_epsilon
|
|
gptkbp:function
|
hydrolyzes phosphatidylinositol 4,5-bisphosphate
generates second messengers diacylglycerol and inositol trisphosphate
|
|
gptkbp:gene
|
gptkb:PLCE1
|
|
gptkbp:involvedIn
|
cell signaling
regulation of cell differentiation
regulation of cell growth
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
10q23.33
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_nephrotic_syndrome
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:UniProtID
|
Q9P212
|
|
gptkbp:bfsParent
|
gptkb:Ras_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLCε
|