Guanine nucleotide exchange factors (GEFs)
GPTKB entity
Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:domain |
gptkb:PH_domain
gptkb:Sec7_domain DH domain |
| gptkbp:enemyOf |
GTPase-activating proteins (GAPs)
|
| gptkbp:example |
gptkb:Dbl
gptkb:RasGRF gptkb:Vav gptkb:SOS1 |
| gptkbp:function |
activate monomeric GTPases
|
| https://www.w3.org/2000/01/rdf-schema#label |
Guanine nucleotide exchange factors (GEFs)
|
| gptkbp:involvedIn |
vesicle trafficking
cell signaling cytoskeletal organization |
| gptkbp:locale |
gptkb:cytoplasm
gptkb:plasma_membrane |
| gptkbp:mechanismOfAction |
promote exchange of GDP for GTP
|
| gptkbp:regulates |
phosphorylation
protein-protein interactions small GTPases |
| gptkbp:relatedTo |
gptkb:cancer
neurological disorders immune response |
| gptkbp:target |
Arf family GTPases
Rab family GTPases Ras family GTPases Rho family GTPases |
| gptkbp:bfsParent |
gptkb:RAS_gene
|
| gptkbp:bfsLayer |
5
|