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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:APPL
gptkb:Adaptor_protein,_phosphotyrosine_interaction,_PH_domain_and_leucine_zipper_containing_1
gptkb:DIP13alpha
|
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gptkbp:associatedWith
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gptkb:type_2_diabetes
insulin resistance
|
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gptkbp:discoveredIn
|
2002
|
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gptkbp:domain
|
gptkb:PH_domain
gptkb:BAR_domain
PTB domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000121022
26060
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
adipose tissue
pancreas
|
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gptkbp:fullName
|
gptkb:Adaptor_protein,_phosphotyrosine_interaction,_PH_domain_and_leucine_zipper_containing_1
|
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gptkbp:function
|
regulates apoptosis
regulates cell proliferation
endosomal adaptor protein
involved in insulin signaling
regulates endosomal trafficking
|
|
gptkbp:gene
|
gptkb:APPL1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:17354
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APPL1
|
|
gptkbp:interactsWith
|
gptkb:AKT2
gptkb:Rab5
gptkb:IRS1
gptkb:GIPC1
gptkb:adiponectin_receptor
|
|
gptkbp:length
|
709 amino acids
|
|
gptkbp:locatedOnChromosome
|
3
|
|
gptkbp:location
|
3p14.3
|
|
gptkbp:molecularWeight
|
75 kDa
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Appl1
|
|
gptkbp:pathway
|
endocytosis
insulin signaling pathway
|
|
gptkbp:regulates
|
cell survival
cell migration
glucose metabolism
insulin sensitivity
endosomal signaling
|
|
gptkbp:UniProtID
|
gptkb:Q9UKG1
|
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gptkbp:bfsParent
|
gptkb:Rab5
|
|
gptkbp:bfsLayer
|
6
|