|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PI3K_pathway
phosphorylation
|
|
gptkbp:alsoKnownAs
|
gptkb:Protein_kinase_B
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:discoveredBy
|
gptkb:Brian_Hemmings
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:domain
|
gptkb:pleckstrin_homology_domain
kinase domain
regulatory domain
|
|
gptkbp:encodedBy
|
gptkb:AKT1_gene
gptkb:AKT3_gene
gptkb:AKT2_gene
|
|
gptkbp:function
|
serine/threonine kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT protein
|
|
gptkbp:inhibitedBy
|
gptkb:MK-2206
gptkb:LY294002
gptkb:wortmannin
gptkb:triciribine
perifosine
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
cell growth
glucose metabolism
apoptosis inhibition
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:regulates
|
gptkb:GSK-3
gptkb:TSC2
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR_pathway
gptkb:NF-κB
gptkb:eNOS
gptkb:p27_Kip1
apoptosis
lipid metabolism
angiogenesis
cell migration
glucose uptake
protein synthesis
cell cycle
insulin signaling
glycogen synthesis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:bfsParent
|
gptkb:PH_domain
gptkb:AKT_oncogene
gptkb:pleckstrin_homology_domain
|
|
gptkbp:bfsLayer
|
7
|