|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
bipolar disorder
|
|
gptkbp:biologicalProcess
|
phosphoric diester hydrolase activity
|
|
gptkbp:CASNumber
|
9001-86-9
|
|
gptkbp:catalyzes
|
hydrolysis of phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Yasutomi_Nishizuka
|
|
gptkbp:EC_number
|
3.1.4.3
|
|
gptkbp:firstDescribed
|
1953
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:gene
|
gptkb:PLCE1
gptkb:PLCG1
gptkb:PLCG2
gptkb:PLCB1
gptkb:PLCB2
gptkb:PLCB3
gptkb:PLCB4
gptkb:PLCD1
gptkb:PLCD3
gptkb:PLCH1
gptkb:PLCH2
PLCD4
PLCZ1
|
|
gptkbp:GO_term
|
GO:0004629
|
|
gptkbp:hasIsoform
|
gptkb:PLCγ
gptkb:PLCε
PLCβ
PLCδ
PLCζ
PLCη
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
phospholipase C
|
|
gptkbp:inhibitedBy
|
gptkb:U73122
edelfosine
|
|
gptkbp:involves
|
signal transduction
|
|
gptkbp:product
|
gptkb:inositol_1,4,5-trisphosphate
diacylglycerol
|
|
gptkbp:regulates
|
intracellular calcium levels
|
|
gptkbp:substrate
|
phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:UniProtID
|
P19174 (PLCG1)
Q9NQ66 (PLCE1)
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsLayer
|
5
|