|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SH2B_adaptor_protein_3
gptkb:LNK
|
|
gptkbp:associatedWith
|
type 1 diabetes
hypertension
autoimmune diseases
myeloproliferative neoplasms
|
|
gptkbp:encodes
|
gptkb:LNK_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000111252
80310
|
|
gptkbp:expressedIn
|
gptkb:thymus
lymph nodes
spleen
bone marrow
hematopoietic cells
peripheral blood leukocytes
|
|
gptkbp:function
|
negative regulation of cytokine signaling
negative regulation of JAK-STAT signaling pathway
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:29671
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SH2B3
|
|
gptkbp:inhibitedBy
|
interleukin signaling
JAK2 signaling
erythropoietin receptor signaling
thrombopoietin receptor signaling
|
|
gptkbp:interactsWith
|
gptkb:JAK2
gptkb:PDGFR
gptkb:LIFR
gptkb:EPOR
gptkb:MPL
gptkb:STAT5
gptkb:c-Kit
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:mutationAssociatedWith
|
gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
|
|
gptkbp:OMIM
|
605093
|
|
gptkbp:orthologInMouse
|
gptkb:Sh2b3
|
|
gptkbp:proteinFamily
|
gptkb:PH_domain
SH2 domain
proline-rich region
|
|
gptkbp:regulates
|
immune response
T cell activation
B cell activation
erythropoiesis
hematopoiesis
platelet production
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:Q9UQQ2
|
|
gptkbp:bfsParent
|
gptkb:chromosome_12
|
|
gptkbp:bfsLayer
|
6
|