|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:TEC
gptkb:Tyrosine-protein_kinase_Tec
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:domain
|
gptkb:PH_domain
kinase domain
SH2 domain
SH3 domain
|
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gptkbp:encodedBy
|
gptkb:TEC_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135605
|
|
gptkbp:expressedIn
|
gptkb:B_cells
gptkb:T_cells
hematopoietic cells
myeloid cells
|
|
gptkbp:family
|
gptkb:Tec_family_tyrosine_kinases
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
regulation of immune response
|
|
gptkbp:HGNC_ID
|
11740
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TEC tyrosine kinase
|
|
gptkbp:inhibitedBy
|
gptkb:acalabrutinib
gptkb:ibrutinib
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:BLNK
gptkb:VAV1
gptkb:GRB2
gptkb:BTK
|
|
gptkbp:length
|
631 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_Xq25
|
|
gptkbp:molecularWeight
|
71 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:OMIM
|
300259
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
proteins involved in immune signaling
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_003215.2
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
gptkb:B-cell_receptor_signaling_pathway
gptkb:T-cell_receptor_signaling_pathway
|
|
gptkbp:structure
|
contains SH2, SH3, PH, and kinase domains
|
|
gptkbp:UniProtID
|
gptkb:P42680
|
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gptkbp:bfsParent
|
gptkb:tyrosine-protein_kinase_Tec
|
|
gptkbp:bfsLayer
|
6
|