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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
|
gptkb:SOS1_protein
gptkb:Son_of_sevenless_homolog_1
|
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gptkbp:associatedWith
|
gptkb:hereditary_gingival_fibromatosis
gptkb:Noonan_syndrome
|
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gptkbp:discoveredIn
|
1993
|
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gptkbp:domain
|
gptkb:PH_domain
CDC25 domain
DH domain
REM domain
proline-rich region
|
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gptkbp:encodedBy
|
gptkb:SOS1_gene
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
guanine nucleotide exchange factor
activates Ras proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOS-1 protein
|
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gptkbp:interactsWith
|
gptkb:SHC1_protein
gptkb:GRB2_protein
gptkb:Ras_protein
|
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gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
signal transduction
|
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gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
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gptkbp:locatedOnChromosome
|
gptkb:2p22-p16_(human_genome)
|
|
gptkbp:molecularWeight
|
~155 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:phosphorylates
|
serine
threonine
|
|
gptkbp:regulates
|
Ras GTPase activity
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB:P18679
|
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gptkbp:bfsParent
|
gptkb:LET-60_protein
|
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gptkbp:bfsLayer
|
6
|