Platelet-derived growth factor receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:PDGFR
gptkbp:associatedWith	gptkb:cancer gptkb:glioblastoma gptkb:chronic_myelomonocytic_leukemia
gptkbp:category	gptkb:tumor_suppressor gptkb:cell_surface_receptor drug target
gptkbp:dimerization	homodimer heterodimer
gptkbp:discoveredIn	1980s
gptkbp:encodedBy	gptkb:PDGFRB_gene gptkb:PDGFRA_gene
gptkbp:function	cell differentiation cell proliferation angiogenesis cell growth regulation
gptkbp:ligand	gptkb:platelet-derived_growth_factor
gptkbp:location	gptkb:cell_membrane
gptkbp:phosphorylates	autophosphorylation upon ligand binding
gptkbp:structure	transmembrane domain extracellular ligand-binding domain intracellular tyrosine kinase domain
gptkbp:subunit	alpha subunit beta subunit
gptkbp:target	gptkb:imatinib gptkb:sunitinib gptkb:crenolanib
gptkbp:type	gptkb:receptor_tyrosine_kinase
gptkbp:UniProtID	gptkb:P09619 P16234
gptkbp:bfsParent	gptkb:PDGFR
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Platelet-derived growth factor receptor