Platelet-derived growth factor receptor

URI: https://gptkb.org/entity/Platelet-derived_growth_factor_receptor
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:PDGFR
gptkbp:associatedWith gptkb:cancer
gptkb:glioblastoma
gptkb:chronic_myelomonocytic_leukemia
gptkbp:category tumor suppressor
cell surface receptor
drug target
gptkbp:dimerization homodimer
heterodimer
gptkbp:discoveredIn 1980s
gptkbp:encodedBy gptkb:PDGFRB_gene
gptkb:PDGFRA_gene
gptkbp:function cell differentiation
cell proliferation
angiogenesis
cell growth regulation
https://www.w3.org/2000/01/rdf-schema#label Platelet-derived growth factor receptor
gptkbp:ligand gptkb:platelet-derived_growth_factor
gptkbp:location gptkb:cell_membrane
gptkbp:phosphorylates autophosphorylation upon ligand binding
gptkbp:structure transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:subunit alpha subunit
beta subunit
gptkbp:target gptkb:imatinib
gptkb:sunitinib
gptkb:crenolanib
gptkbp:type gptkb:receptor_tyrosine_kinase
gptkbp:UniProtID gptkb:P09619
P16234
gptkbp:bfsParent gptkb:PDGFR
gptkbp:bfsLayer 6