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gptkbp:instanceOf
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gptkb:protein
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gptkbp:associatedWith
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gptkb:cancer
signal transduction
cell cycle regulation
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gptkbp:describes
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This domain is found in protein kinases, which are enzymes that transfer phosphate groups from ATP to a protein substrate.
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gptkbp:enzymeCommissionNumber
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gptkb:EC_2.7.11.-
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gptkbp:foundIn
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prokaryotes
eukaryotes
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gptkbp:function
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catalyzes phosphorylation of proteins
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gptkbp:hasConservedResidues
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activation segment
catalytic aspartate
glycine-rich loop
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gptkbp:hasDomainArchitecture
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bilobal structure
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gptkbp:hasGOAnnotation
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GO:0004672 (protein kinase activity)
GO:0006468 (protein phosphorylation)
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gptkbp:hasPfamAccession
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gptkb:PF00069
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gptkbp:hasPfamClan
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gptkb:CL0016_(Protein_kinase-like_domain_superfamily)
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gptkbp:hasPfamType
|
Domain
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gptkbp:hasRepresentativeStructure
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gptkb:PDB:1ATP
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gptkbp:hasSCOPeDomain
|
d.144.1.7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PF00069
|
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gptkbp:InterPro
|
gptkb:IPR000719
|
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gptkbp:length
|
~250-300 amino acids
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gptkbp:name
|
gptkb:Protein_kinase_domain
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gptkbp:partOf
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gptkb:Pfam_database
|
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gptkbp:presentIn
|
serine/threonine kinases
tyrosine kinases
dual-specificity kinases
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gptkbp:substrate
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gptkb:ATP
gptkb:protein
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gptkbp:target
|
kinase inhibitors
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gptkbp:bfsParent
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gptkb:P15056
gptkb:P42338
gptkb:protein_kinase_superfamily
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gptkbp:bfsLayer
|
6
|