|
gptkbp:instanceOf
|
gptkb:cell_surface_receptor
gptkb:enzyme
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alternativeName
|
gptkb:RTK
|
|
gptkbp:catalyzes
|
phosphorylation of tyrosine residues
|
|
gptkbp:contains
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:discoveredBy
|
1970s
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
developmental disorders
|
|
gptkbp:example
|
gptkb:EGFR
gptkb:FGFR
gptkb:Insulin_receptor
gptkb:PDGFR
gptkb:VEGFR
Trk receptor
|
|
gptkbp:foundIn
|
animals
humans
fungi
plants
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:involves
|
cell differentiation
cell survival
cell growth
cell migration
cell metabolism
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mechanismOfAction
|
dimerization
autophosphorylation
|
|
gptkbp:number_of_subfamilies
|
20
|
|
gptkbp:proteinFamily
|
RTK family
|
|
gptkbp:target
|
tyrosine kinase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:P42338
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Receptor tyrosine kinase
|