Statements (37)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
cell surface receptor |
| gptkbp:activatedBy |
ligand binding
|
| gptkbp:alternativeName |
gptkb:RTK
|
| gptkbp:catalyzes |
phosphorylation of tyrosine residues
|
| gptkbp:contains |
transmembrane domain
extracellular ligand-binding domain intracellular tyrosine kinase domain |
| gptkbp:discoveredBy |
1970s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes developmental disorders |
| gptkbp:example |
gptkb:EGFR
gptkb:FGFR gptkb:Insulin_receptor gptkb:PDGFR gptkb:VEGFR Trk receptor |
| gptkbp:foundIn |
animals
humans fungi plants |
| gptkbp:function |
signal transduction
|
| https://www.w3.org/2000/01/rdf-schema#label |
Receptor tyrosine kinase
|
| gptkbp:involves |
cell differentiation
cell survival cell growth cell migration cell metabolism |
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:mechanismOfAction |
dimerization
autophosphorylation |
| gptkbp:number_of_subfamilies |
20
|
| gptkbp:proteinFamily |
RTK family
|
| gptkbp:target |
tyrosine kinase inhibitors
|
| gptkbp:bfsParent |
gptkb:P42338
|
| gptkbp:bfsLayer |
6
|