|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:cellular_tumor_antigen_p53
gptkb:antigen_NY-CO-13
gptkb:phosphoprotein_p53
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
|
|
gptkbp:biologicalProcess
|
apoptosis
DNA repair
senescence
cell cycle arrest
angiogenesis inhibition
|
|
gptkbp:domain
|
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:GOID
|
gptkb:GO:0008285
GO:0003677
GO:0006355
GO:0006915
|
|
gptkbp:hasIsoform
|
gptkb:p53α
gptkb:p53β
gptkb:p53γ
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NP 000724
|
|
gptkbp:interactsWith
|
gptkb:CREBBP
gptkb:EP300
gptkb:TP53BP1
gptkb:BAX
gptkb:MDM2
gptkb:BRCA1
gptkb:p21_(CDKN1A)
ATM
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
codon 175
codon 248
codon 273
codon 282
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Trp53
gptkb:rat_Tp53
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:refersTo
|
Tumor protein p53
|
|
gptkbp:sequence
|
393 amino acids
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:CD3E
|
|
gptkbp:bfsLayer
|
7
|