|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:antibody_target
|
gptkb:OKT3
|
|
gptkbp:associatedWith
|
gptkb:Immunodeficiency_18
gptkb:Severe_combined_immunodeficiency
|
|
gptkbp:cell_type_expression
|
gptkb:NK_cells
T lymphocytes
|
|
gptkbp:component
|
gptkb:T-cell_receptor-CD3_complex
|
|
gptkbp:cytoplasmic_ITAM_motif
|
yes
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:encodes
|
gptkb:CD3-epsilon_protein
|
|
gptkbp:Entrez_Gene_ID
|
916
ENSG00000198851
GC11M118425
|
|
gptkbp:expressedIn
|
gptkb:thymus
spleen
peripheral blood
|
|
gptkbp:fullName
|
gptkb:CD3e_molecule,_epsilon_(CD3-TCR_complex)
|
|
gptkbp:function
|
signal transduction
T-cell activation
|
|
gptkbp:gene
|
gptkb:CD3E
|
|
gptkbp:GO_term
|
gptkb:T_cell_receptor_complex
immune response
protein binding
|
|
gptkbp:HGNC_ID
|
1675
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD3E
|
|
gptkbp:interactsWith
|
gptkb:CD3G
gptkb:TCR_alpha_chain
gptkb:TCR_beta_chain
gptkb:CD3D
CD247 (CD3Z)
|
|
gptkbp:locatedOnChromosome
|
11
11q23.3
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
20-22 kDa
|
|
gptkbp:OMIM
|
186830
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cd3e
|
|
gptkbp:PDB
|
gptkb:1SY6
1XIW
|
|
gptkbp:RefSeq
|
gptkb:NM_000733
gptkb:NP_000724
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:significance
|
diagnostic marker for T cells
immunotherapy target
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P07766
|
|
gptkbp:bfsParent
|
gptkb:immunodeficiency
|
|
gptkbp:bfsLayer
|
6
|