|
gptkbp:instanceOf
|
immune response
lymphocyte
|
|
gptkbp:activatedBy
|
gptkb:interleukin-2
gptkb:interleukin-12
gptkb:interleukin-15
gptkb:interleukin-18
|
|
gptkbp:cytotoxicMechanism
|
induction of apoptosis
release of cytotoxic granules
|
|
gptkbp:developedBy
|
common lymphoid progenitor
|
|
gptkbp:discoveredBy
|
gptkb:Rolf_Kiessling
gptkb:Eva_Klein
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:expressedIn
|
gptkb:FcγRIII_(CD16)
|
|
gptkbp:foundIn
|
lymph nodes
spleen
bone marrow
peripheral blood
|
|
gptkbp:fullName
|
natural killer cell
|
|
gptkbp:function
|
cytotoxicity
immune surveillance
killing tumor cells
killing virus-infected cells
|
|
gptkbp:hasNo
|
gptkb:CD3
cell surface receptor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NK cell
|
|
gptkbp:inhibitedBy
|
gptkb:MHC_class_I_molecules
|
|
gptkbp:marking
|
gptkb:CD56
gptkb:NKG2D
gptkb:NCAM1
KIR
CD16
|
|
gptkbp:medicalUse
|
gptkb:CAR-NK_therapy
adoptive cell therapy
|
|
gptkbp:proportionOfLymphocytes
|
5-20% in peripheral blood
|
|
gptkbp:relatedTo
|
gptkb:B_cell
gptkb:adaptive_immune_system
cell surface receptor
innate immune system
|
|
gptkbp:role
|
immunotherapy
viral infection response
cancer immunosurveillance
|
|
gptkbp:secretes
|
gptkb:interferon-gamma
gptkb:perforin
gptkb:granzyme_B
|
|
gptkbp:surfaceProtein
|
gptkb:NKp30
gptkb:NKp44
gptkb:NKp46
gptkb:CD94
gptkb:NKG2A
|
|
gptkbp:bfsParent
|
gptkb:Natural_Killer_cell
|
|
gptkbp:bfsLayer
|
7
|