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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Natural_cytotoxicity_triggering_receptor_1
gptkb:NCR1
|
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gptkbp:cellularComponent
|
gptkb:cell_membrane
|
|
gptkbp:discoveredBy
|
late 1990s
|
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gptkbp:encodedBy
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gptkb:NCR1_gene
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gptkbp:Entrez_Gene_ID
|
9437 (human)
|
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gptkbp:expressedIn
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gptkb:natural_killer_cells
|
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gptkbp:foundIn
|
humans
mice
|
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gptkbp:function
|
activating receptor
mediates cytotoxicity
recognizes tumor cells
recognizes virus-infected cells
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gptkbp:GO_term
|
gptkb:GO:0001772_(natural_killer_cell_mediated_immunity)
gptkb:GO:0045087_(innate_immune_response)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NKp46
|
|
gptkbp:interactsWith
|
gptkb:CD3ζ
gptkb:FcεRIγ
|
|
gptkbp:ligand
|
viral hemagglutinins
unknown cellular ligands
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_19q13.4_(human)
|
|
gptkbp:molecularWeight
|
~46 kDa
|
|
gptkbp:orthologIn
|
mouse Ncr1
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:role
|
innate immunity
tumor surveillance
antiviral response
|
|
gptkbp:structure
|
contains two Ig-like domains
|
|
gptkbp:UniProtID
|
gptkb:O76036
|
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gptkbp:bfsParent
|
gptkb:Natural_Killer_cell
|
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gptkbp:bfsLayer
|
7
|