|
gptkbp:instanceOf
|
gptkb:serine_protease
gptkb:enzyme
|
|
gptkbp:cleavage
|
gptkb:DNA-PK
procaspase-3
procaspase-7
poly(ADP-ribose) polymerase (PARP)
alpha-fodrin
lamin B
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:EC_number
|
3.4.21.79
|
|
gptkbp:encodedBy
|
gptkb:GZMB_gene
|
|
gptkbp:Entrez_Gene_ID
|
3002
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
activated CD8+ T cells
|
|
gptkbp:foundIn
|
gptkb:natural_killer_cells
cytotoxic T lymphocytes
|
|
gptkbp:function
|
induces apoptosis in target cells
|
|
gptkbp:HGNC_ID
|
4706
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
granzyme B
|
|
gptkbp:inhibitedBy
|
gptkb:serpins
|
|
gptkbp:involvedIn
|
immune response
cell-mediated cytotoxicity
|
|
gptkbp:locale
|
cytoplasmic granules
|
|
gptkbp:locatedOnChromosome
|
chromosome 14q11.2
|
|
gptkbp:mechanismOfAction
|
activates caspases
cleaves BID protein
cleaves after aspartic acid residues
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:OMIM
|
600818
|
|
gptkbp:orthologInMouse
|
Gzmb
|
|
gptkbp:PDB
|
1IAU
|
|
gptkbp:relatedTo
|
gptkb:perforin
gptkb:granzyme_A
|
|
gptkbp:releaseYear
|
exocytosis of cytotoxic granules
|
|
gptkbp:role
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
viral infections
transplant rejection
|
|
gptkbp:structure
|
contains a serine protease domain
|
|
gptkbp:substrate
|
gptkb:caspase-3
gptkb:caspase-7
gptkb:BID
gptkb:ICAD
|
|
gptkbp:UniProtID
|
P10144
|
|
gptkbp:usedAs
|
marker for cytotoxic lymphocytes
|
|
gptkbp:usedIn
|
immunohistochemistry
|
|
gptkbp:bfsParent
|
gptkb:granzymes
|
|
gptkbp:bfsLayer
|
6
|