interleukin-15

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf cytokine
gptkbp:alternativeSplicing yes
gptkbp:binds gptkb:IL-15Rα
gptkb:IL-2/15Rβ
gptkb:common_gamma_chain_(γc)
gptkbp:clinicalTrialPhase gptkb:ALT-803
gptkbp:discoveredBy 1994
gptkbp:encodedBy gptkb:IL15_gene
gptkbp:Entrez_Gene_ID 3600
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function immune system regulation
T cell proliferation
NK cell activation
gptkbp:HGNC_ID 5977
https://www.w3.org/2000/01/rdf-schema#label interleukin-15
gptkbp:involvedIn autoimmune diseases
inflammatory response
gptkbp:locatedOnChromosome 4q31
gptkbp:molecularWeight 14-15 kDa
gptkbp:OMIM 600554
gptkbp:orthologIn gptkb:bovine_IL-15
gptkb:mouse_IL-15
gptkb:rat_IL-15
gptkbp:PDB 1ILK
gptkbp:producedBy gptkb:skeletal_muscle
gptkb:keratinocytes
fibroblasts
gptkbp:promotion differentiation of T cells
proliferation of NK cells
gptkbp:recipient gptkb:IL-15_receptor
gptkbp:regulates lymphocyte homeostasis
NK cell development
memory T cell survival
gptkbp:relatedTo gptkb:interleukin-2
gptkbp:role multiple sclerosis
celiac disease
inflammatory bowel disease
antiviral immunity
allograft rejection
antitumor immunity
gptkbp:secretes dendritic cells
macrophages
monocytes
gptkbp:structure four alpha-helix bundle
gptkbp:symbol gptkb:IL-15
gptkbp:therapeuticArea immunotherapy
rheumatoid arthritis
gptkbp:UniProtID P40933
gptkbp:bfsParent gptkb:Natural_Killer_cell
gptkbp:bfsLayer 7