|
gptkbp:instanceOf
|
gptkb:cytokine
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:IL-15Rα
gptkb:IL-2/15Rβ
gptkb:common_gamma_chain_(γc)
|
|
gptkbp:clinicalTrialPhase
|
gptkb:ALT-803
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:encodedBy
|
gptkb:IL15_gene
|
|
gptkbp:Entrez_Gene_ID
|
3600
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
immune system regulation
T cell proliferation
NK cell activation
|
|
gptkbp:HGNC_ID
|
5977
|
|
gptkbp:involvedIn
|
autoimmune diseases
inflammatory response
|
|
gptkbp:locatedOnChromosome
|
4q31
|
|
gptkbp:molecularWeight
|
14-15 kDa
|
|
gptkbp:OMIM
|
600554
|
|
gptkbp:orthologIn
|
gptkb:bovine_IL-15
gptkb:mouse_IL-15
gptkb:rat_IL-15
|
|
gptkbp:PDB
|
1ILK
|
|
gptkbp:producedBy
|
gptkb:skeletal_muscle
gptkb:keratinocytes
fibroblasts
|
|
gptkbp:promotion
|
differentiation of T cells
proliferation of NK cells
|
|
gptkbp:recipient
|
gptkb:IL-15_receptor
|
|
gptkbp:regulates
|
lymphocyte homeostasis
NK cell development
memory T cell survival
|
|
gptkbp:relatedTo
|
gptkb:interleukin-2
|
|
gptkbp:role
|
gptkb:inflammatory_bowel_disease
multiple sclerosis
celiac disease
antiviral immunity
allograft rejection
antitumor immunity
|
|
gptkbp:secretes
|
dendritic cells
macrophages
monocytes
|
|
gptkbp:structure
|
four alpha-helix bundle
|
|
gptkbp:symbol
|
gptkb:IL-15
|
|
gptkbp:therapeuticArea
|
gptkb:immunotherapy
rheumatoid arthritis
|
|
gptkbp:UniProtID
|
P40933
|
|
gptkbp:bfsParent
|
gptkb:Natural_Killer_cell
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-15
|