|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:JNK1
gptkb:c-Jun_N-terminal_kinase_1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:Mitogen-activated_protein_kinase_8
|
|
gptkbp:Entrez_Gene_ID
|
5599
ENSG00000107643
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
protein serine/threonine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
response to stress
regulation of apoptotic process
|
|
gptkbp:HGNC_ID
|
6881
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK8 gene
|
|
gptkbp:inhibitedBy
|
gptkb:SP600125
gptkb:JNK-IN-8
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
apoptosis
cell differentiation
cell proliferation
stress response
|
|
gptkbp:length
|
427 amino acids
~21 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:numberOfExons
|
13
|
|
gptkbp:OMIM
|
601158
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk8
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:Elk-1
gptkb:c-Jun
Thr183
Tyr185
|
|
gptkbp:proteinFamily
|
gptkb:MAP_kinase_family
Serine/threonine protein kinase
|
|
gptkbp:regulates
|
gptkb:MAP2K4
gptkb:MAP2K7
gptkb:MAP3K1
transcription factors
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P45983
|
|
gptkbp:bfsParent
|
gptkb:JNK
gptkb:JNK1
gptkb:Mitogen-activated_protein_kinase_8
gptkb:c-Jun_N-terminal_kinase_1
|
|
gptkbp:bfsLayer
|
7
|