|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activeSiteResidue
|
zinc-binding motif
|
|
gptkbp:alsoKnownAs
|
gptkb:stromelysin-1
|
|
gptkbp:associatedWith
|
gptkb:cancer
osteoarthritis
rheumatoid arthritis
|
|
gptkbp:cleavage
|
gptkb:fibronectin
gptkb:laminin
collagen
gelatin
proteoglycans
|
|
gptkbp:encodes
|
gptkb:matrix_metalloproteinase-3
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000149968
4314
|
|
gptkbp:enzymeCommissionNumber
|
3.4.24.17
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
collagen
synovial tissue
|
|
gptkbp:fullName
|
gptkb:Matrix_metallopeptidase_3
|
|
gptkbp:function
|
degrades extracellular matrix proteins
involved in arthritis
involved in tissue remodeling
involved in wound healing
|
|
gptkbp:hasBiomarker
|
gptkb:cardiovascular_disease
joint disease
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:7156
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP3
|
|
gptkbp:inhibitedBy
|
gptkb:TIMP1
gptkb:TIMP2
gptkb:TIMP3
gptkb:TIMP4
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q22.2
chromosome 11
|
|
gptkbp:memberOf
|
gptkb:matrix_metalloproteinase_family
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:OMIM
|
185250
|
|
gptkbp:orthologInMouse
|
gptkb:Mmp3
|
|
gptkbp:PDB
|
gptkb:1CQR
1G4K
|
|
gptkbp:product
|
zinc-dependent endopeptidase
|
|
gptkbp:regulates
|
cytokines
growth factors
AP-1 binding site
NF-κB binding site
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:P08254
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|