|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
kidney disease
neurodegenerative disease
inflammation
metastasis
fibrosis
tissue remodeling
|
|
gptkbp:discoveredBy
|
gptkb:Stetler-Stevenson_et_al.
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:encodedBy
|
gptkb:TIMP2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000110330
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:family
|
gptkb:TIMP_family
|
|
gptkbp:fullName
|
gptkb:Tissue_inhibitor_of_metalloproteinases_2
|
|
gptkbp:function
|
inhibits matrix metalloproteinases (MMPs)
regulates extracellular matrix composition
|
|
gptkbp:gene
|
gptkb:TIMP2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11822
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIMP2
|
|
gptkbp:inhibitedBy
|
gptkb:MMP2
gptkb:MMP9
|
|
gptkbp:interactsWith
|
gptkb:MMP14
gptkb:pro-MMP2
|
|
gptkbp:length
|
220 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q25
|
|
gptkbp:molecularWeight
|
24 kDa
|
|
gptkbp:numberInFamily
|
2
|
|
gptkbp:OMIM
|
188825
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1BR9
|
|
gptkbp:postTranslationalModification
|
gptkb:N-glycosylation
|
|
gptkbp:RefSeq
|
gptkb:NM_003255
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell migration
regulated by growth factors
regulated by cytokines
transcriptionally regulated
|
|
gptkbp:relatedTo
|
angiogenesis
cancer progression
extracellular matrix remodeling
|
|
gptkbp:significance
|
biomarker for cancer and fibrosis
|
|
gptkbp:structure
|
contains N-terminal and C-terminal domains
|
|
gptkbp:subcellularLocation
|
extracellular space
|
|
gptkbp:UniProtID
|
P16035
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|