matrix metalloproteinase family
GPTKB entity
Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
MMP family
|
| gptkbp:cofactor |
zinc
calcium |
| gptkbp:component |
extracellular region
|
| gptkbp:contains |
gptkb:matrix_metalloproteinase-3
gptkb:matrix_metalloproteinase-7 matrix metalloproteinase-1 matrix metalloproteinase-13 matrix metalloproteinase-14 matrix metalloproteinase-2 matrix metalloproteinase-8 matrix metalloproteinase-9 |
| gptkbp:discoveredBy |
Hideaki Nagase
|
| gptkbp:EC_number |
3.4.24.-
|
| gptkbp:enzymeClassification |
endopeptidase
|
| gptkbp:firstDescribed |
1962
|
| gptkbp:function |
metalloendopeptidase activity
degradation of extracellular matrix proteins |
| gptkbp:GOProcess |
extracellular matrix disassembly
|
| https://www.w3.org/2000/01/rdf-schema#label |
matrix metalloproteinase family
|
| gptkbp:inhibitedBy |
tissue inhibitor of metalloproteinases
|
| gptkbp:involvedIn |
wound healing
angiogenesis cancer metastasis tissue remodeling |
| gptkbp:locatedOnChromosome |
chromosome 11 (MMP1, MMP3, MMP7, MMP8, MMP10, MMP12, MMP13, MMP20, MMP27)
chromosome 16 (MMP2) chromosome 20 (MMP9) |
| gptkbp:OMIM |
120353 (MMP1)
120360 (MMP2) 120361 (MMP9) |
| gptkbp:orthologIn |
gptkb:fish
birds amphibians invertebrates mammals reptiles |
| gptkbp:regulates |
transcriptional control
inhibition by TIMPs proteolytic activation |
| gptkbp:relatedTo |
gptkb:cardiovascular_disease
neurodegenerative disease arthritis fibrosis |
| gptkbp:structure |
catalytic domain
hemopexin-like domain propeptide domain |
| gptkbp:UniProtID |
P08253 (MMP2)
P14780 (MMP9) P33430 (MMP1) |
| gptkbp:bfsParent |
gptkb:MMP2
gptkb:MMP3 gptkb:MMP7 |
| gptkbp:bfsLayer |
7
|