|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
CYP2E
cytochrome P450-J
microsomal ethanol oxidase
|
|
gptkbp:associatedWith
|
cancer susceptibility
drug-induced liver injury
alcohol-induced liver disease
|
|
gptkbp:biologicalProcess
|
monooxygenase activity
heme binding
iron ion binding
oxidation-reduction process
xenobiotic metabolic process
|
|
gptkbp:cellularComponent
|
endoplasmic reticulum membrane
microsome
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:enzymeCommissionNumber
|
1.14.14.1
|
|
gptkbp:gene
|
CYP2E1
|
|
gptkbp:gene_ID_(Ensembl)
|
ENSG00000130649
|
|
gptkbp:gene_ID_(Entrez)
|
1571
|
|
gptkbp:gene_ID_(HGNC)
|
2597
|
|
gptkbp:gene_ID_(OMIM)
|
124040
|
|
gptkbp:gene_ID_(RefSeq)
|
NM_000773
|
|
gptkbp:gene_ID_(UniGene)
|
Hs.654
|
|
gptkbp:hasPolymorphism
|
CYP2E1*5B
CYP2E1*6
CYP2E1*7B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P08254
|
|
gptkbp:length
|
493
|
|
gptkbp:locatedOnChromosome
|
10
CYP2E1
|
|
gptkbp:location
|
10q26.3
|
|
gptkbp:molecularWeight
|
56,841
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
drug metabolism - cytochrome P450
metabolism of xenobiotics by cytochrome P450
|
|
gptkbp:protein_name
|
Cytochrome P450 2E1
|
|
gptkbp:structure
|
contains a heme-binding domain
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
microsomal fraction
|
|
gptkbp:substrate
|
gptkb:chloroform
ethanol
benzene
acetaminophen
aniline
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:kidney
brain
liver
|
|
gptkbp:UniProtID
|
gptkb:P08254
|
|
gptkbp:bfsParent
|
gptkb:MMP3
|
|
gptkbp:bfsLayer
|
7
|