|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Erythroid_potentiating_activity_(EPA)
gptkb:Metalloproteinase_inhibitor_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:liver_disease
fibrosis
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:encodedBy
|
gptkb:TIMP1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000102265
|
|
gptkbp:expressedIn
|
expressed in many tissues
upregulated in inflammation
|
|
gptkbp:fullName
|
gptkb:Tissue_inhibitor_of_metalloproteinases_1
|
|
gptkbp:function
|
involved in apoptosis
involved in cell proliferation
inhibits matrix metalloproteinases (MMPs)
involved in tissue remodeling
regulates extracellular matrix composition
|
|
gptkbp:gene
|
gptkb:TIMP1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11820
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIMP1
|
|
gptkbp:interactsWith
|
gptkb:CD63
gptkb:MMP1
gptkb:MMP2
gptkb:MMP3
gptkb:MMP9
|
|
gptkbp:length
|
207 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xp11.3–p11.23
|
|
gptkbp:molecularWeight
|
~28 kDa
|
|
gptkbp:OMIM
|
305370
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus_TIMP1
gptkb:Rattus_norvegicus_TIMP1
gptkb:mouse_TIMP1
|
|
gptkbp:pathway
|
gptkb:ECM-receptor_interaction
gptkb:Focal_adhesion
gptkb:Proteoglycans_in_cancer
|
|
gptkbp:PDB
|
gptkb:1UEA
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:TIMP_family
|
|
gptkbp:RefSeq
|
gptkb:NM_003254
|
|
gptkbp:significance
|
biomarker for cancer
implicated in cardiovascular disease
implicated in fibrosis
|
|
gptkbp:structure
|
contains N-terminal and C-terminal domains
|
|
gptkbp:subcellularLocation
|
secreted
|
|
gptkbp:UniProtID
|
gptkb:P01033
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|