matrix metalloproteinase-3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	activated by proteolytic cleavage secreted as inactive proenzyme other matrix metalloproteinases
gptkbp:alternativeName	gptkb:stromelysin-1
gptkbp:associatedWith	osteoarthritis cancer progression rheumatoid arthritis
gptkbp:discoveredBy	gptkb:G._Murphy_et_al.
gptkbp:discoveredIn	1977
gptkbp:EC_number	3.4.24.17
gptkbp:encodedBy	MMP3 gene
gptkbp:Entrez_Gene_ID	4314
gptkbp:expressedIn	gptkb:skeletal_muscle collagen synovial tissue
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	degrades extracellular matrix proteins involved in arthritis involved in tissue remodeling involved in wound healing
gptkbp:GO_term	GO:0004222 (metalloendopeptidase activity) GO:0006508 (proteolysis)
https://www.w3.org/2000/01/rdf-schema#label	matrix metalloproteinase-3
gptkbp:inhibitedBy	gptkb:tissue_inhibitors_of_metalloproteinases_(TIMPs)
gptkbp:locatedOnChromosome	gptkb:11q22.3
gptkbp:molecularWeight	45 kDa (active form) 54 kDa (proenzyme)
gptkbp:OMIM	185250
gptkbp:PDB	gptkb:1CQR
gptkbp:relatedTo	gptkb:matrix_metalloproteinase_family
gptkbp:structure	contains a hemopexin-like domain contains a zinc-binding catalytic domain
gptkbp:substrate	gptkb:fibronectin gptkb:laminin collagen gelatin proteoglycans
gptkbp:UniProtID	gptkb:P08254
gptkbp:bfsParent	gptkb:MMP3
gptkbp:bfsLayer	7