Matrix metallopeptidase 3

URI: https://gptkb.org/entity/Matrix_metallopeptidase_3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:stromelysin-1 proteoglycanase transin
gptkbp:associatedWith	gptkb:cardiovascular_disease osteoarthritis cancer progression rheumatoid arthritis
gptkbp:cleavage	pro-MMP1 pro-MMP13 pro-MMP14 pro-MMP7 pro-MMP8 pro-MMP9
gptkbp:cofactor	zinc calcium
gptkbp:discoveredBy	Okada et al.
gptkbp:discoveredIn	1980
gptkbp:EC_number	3.4.24.17
gptkbp:encodedBy	MMP3 gene
gptkbp:Entrez_Gene_ID	4314 GC11M079282
gptkbp:enzymeClassification	metalloproteinase
gptkbp:family	gptkb:matrix_metalloproteinase_family
gptkbp:function	degrades extracellular matrix proteins involved in arthritis involved in tissue remodeling involved in wound healing involved in metastasis
gptkbp:HGNC_ID	7154
https://www.w3.org/2000/01/rdf-schema#label	Matrix metallopeptidase 3
gptkbp:locatedIn	extracellular matrix
gptkbp:locatedOnChromosome	gptkb:11q22.3
gptkbp:molecularWeight	45 kDa (active form) 54 kDa (proenzyme)
gptkbp:OMIM	185250
gptkbp:PDB	gptkb:1CQR
gptkbp:regulates	activated by proteolytic cleavage inhibited by TIMPs
gptkbp:species	gptkb:Homo_sapiens
gptkbp:substrate	gptkb:fibronectin gptkb:elastin gptkb:laminin collagen gelatin proteoglycans
gptkbp:UniProtID	gptkb:P08254
gptkbp:bfsParent	gptkb:MMP3
gptkbp:bfsLayer	7