|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:72_kDa_type_IV_collagenase
gptkb:gelatinase_A
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
arthritis
cancer metastasis
|
|
gptkbp:cofactor
|
zinc
calcium
|
|
gptkbp:discoveredBy
|
gptkb:G._Murphy
|
|
gptkbp:encodedBy
|
gptkb:MMP2_gene
|
|
gptkbp:Entrez_Gene_ID
|
4313
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.4.24.24
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
fibroblasts
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_2
|
|
gptkbp:function
|
degradation of extracellular matrix
cleavage of type IV collagen
|
|
gptkbp:GO_term
|
GO:0004222
GO:0005578
GO:0006508
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP2
|
|
gptkbp:inhibitedBy
|
gptkb:TIMP1
gptkb:TIMP2
|
|
gptkbp:locatedOnChromosome
|
gptkb:16q12.2
|
|
gptkbp:location
|
extracellular space
secreted
|
|
gptkbp:memberOf
|
gptkb:matrix_metalloproteinase_family
|
|
gptkbp:molecularWeight
|
72 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:multicentric_osteolysis_nodulosis_arthropathy
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:ECM-receptor_interaction
gptkb:Focal_adhesion
gptkb:Proteoglycans_in_cancer
|
|
gptkbp:PDB
|
1CK7
|
|
gptkbp:RefSeq
|
NM_004530
|
|
gptkbp:regulates
|
activated by proteolytic cleavage
|
|
gptkbp:structure
|
contains catalytic domain
contains fibronectin type II-like repeats
contains hemopexin-like domain
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:type_IV_collagen
gptkb:laminin
gelatin
|
|
gptkbp:targetOfDrug
|
inhibitors under investigation for cancer and fibrosis
|
|
gptkbp:UniProtID
|
P08253
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|