Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:alsoKnownAs |
gptkb:MMP-2
matrix metalloproteinase-2 |
| gptkbp:cofactor |
zinc
calcium |
| gptkbp:EC_number |
3.4.24.24
|
| gptkbp:expressedIn |
endothelial cells
fibroblasts tumor cells |
| gptkbp:family |
gptkb:matrix_metalloproteinases
|
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
degrades type IV collagen
involved in extracellular matrix remodeling |
| gptkbp:gene |
gptkb:MMP2
|
| https://www.w3.org/2000/01/rdf-schema#label |
72 kDa type IV collagenase
|
| gptkbp:inhibitedBy |
gptkb:tissue_inhibitors_of_metalloproteinases_(TIMPs)
|
| gptkbp:locatedOnChromosome |
human chromosome 16q13-q21
|
| gptkbp:molecularWeight |
72 kDa
|
| gptkbp:OMIM |
120360
|
| gptkbp:role |
gptkb:cardiovascular_disease
arthritis cancer metastasis |
| gptkbp:structure |
contains fibronectin type II-like repeats
contains hemopexin-like domain |
| gptkbp:substrate |
gptkb:elastin
gptkb:type_IV_collagen gelatin |
| gptkbp:UniProtID |
P08253
|
| gptkbp:bfsParent |
gptkb:MMP2
|
| gptkbp:bfsLayer |
7
|