Statements (40)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:alsoKnownAs |
gptkb:gelatinase_A
|
| gptkbp:associatedWith |
gptkb:cardiovascular_disease
arthritis metastasis tumor invasion |
| gptkbp:EC_number |
3.4.24.24
|
| gptkbp:encodedBy |
gptkb:MMP2_gene
|
| gptkbp:expressedIn |
macrophages
endothelial cells fibroblasts |
| gptkbp:family |
gptkb:matrix_metalloproteinase
|
| gptkbp:function |
degradation of extracellular matrix
cleavage of type IV collagen |
| gptkbp:gene |
gptkb:MMP2
|
| gptkbp:HGNC_ID |
HGNC:7155
|
| https://www.w3.org/2000/01/rdf-schema#label |
matrix metallopeptidase 2
|
| gptkbp:inhibitedBy |
gptkb:TIMP1
gptkb:TIMP2 |
| gptkbp:locatedOnChromosome |
gptkb:16q12.2
|
| gptkbp:molecularWeight |
72 kDa
|
| gptkbp:OMIM |
120360
|
| gptkbp:PDB |
1CK7
1EAK 1GXD 1QIB |
| gptkbp:substrate |
gptkb:fibronectin
gptkb:collagen_type_I gptkb:elastin gptkb:collagen_type_IV gptkb:laminin gelatin collagen type V collagen type VII collagen type X |
| gptkbp:UniProtID |
P08253
|
| gptkbp:bfsParent |
gptkb:MMP2
|
| gptkbp:bfsLayer |
7
|