|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:gelatinase_A
type IV collagenase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:TIMP2_gene
multicentric osteolysis, nodulosis, and arthropathy
MMP9 gene
MT1-MMP gene
Torg-Winchester syndrome
|
|
gptkbp:cleavage
|
Gly-Leu bond in collagen
|
|
gptkbp:cofactor
|
zinc
calcium
|
|
gptkbp:discoveredBy
|
Okada et al.
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:encodes
|
MMP-2 protein
|
|
gptkbp:Entrez_Gene_ID
|
4313
ENSG00000087245
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.4.24.24
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:matrix_metallopeptidase_2
|
|
gptkbp:function
|
angiogenesis
cell migration
degradation of extracellular matrix
tissue remodeling
tumor invasion
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:7166
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MMP2 gene
|
|
gptkbp:length
|
660 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16q12.2
|
|
gptkbp:mutationAssociatedWith
|
skeletal abnormalities
joint destruction
|
|
gptkbp:OMIM
|
120360
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Mmp2
|
|
gptkbp:pathway
|
wound healing
metastasis
inflammatory response
ECM degradation
|
|
gptkbp:product
|
contains catalytic domain
contains hemopexin-like domain
contains fibronectin type II domains
|
|
gptkbp:proteinFamily
|
gptkb:matrix_metalloproteinases
|
|
gptkbp:regulates
|
inhibited by TIMP2
activated by MT1-MMP
|
|
gptkbp:substrate
|
gptkb:fibronectin
gptkb:elastin
gptkb:aggrecan
gptkb:collagen_type_IV
gptkb:laminin
gelatin
|
|
gptkbp:UniProtID
|
P08253
|
|
gptkbp:bfsParent
|
gptkb:MMP2
|
|
gptkbp:bfsLayer
|
7
|