|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:CD10
gptkb:neprilysin
enkephalinase
neutral endopeptidase
|
|
gptkbp:CASNumber
|
9075-59-4
|
|
gptkbp:catalyzes
|
hydrolysis of peptides, especially on the amino side of hydrophobic residues
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:EC_number
|
3.4.24.24
|
|
gptkbp:family
|
peptidase M13 family
|
|
gptkbp:foundIn
|
gptkb:cancer
gptkb:cell_membrane
gptkb:kidney
brain
neutrophils
|
|
gptkbp:function
|
degradation of regulatory peptides
|
|
gptkbp:gene
|
gptkb:MME
|
|
gptkbp:GO_term
|
GO:0004263
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EC 3.4.24.24
|
|
gptkbp:inhibitedBy
|
phosphoramidon
thiorphan
|
|
gptkbp:InterPro
|
IPR000718
|
|
gptkbp:locatedOnChromosome
|
human chromosome 3q25
|
|
gptkbp:MEROPS
|
M13.001
|
|
gptkbp:OMIM
|
120520
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1DMT
1R1H
4CTH
|
|
gptkbp:proteinFamily
|
PF01431
|
|
gptkbp:significance
|
implicated in Alzheimer's disease
implicated in hypertension
implicated in heart failure
marker for acute lymphoblastic leukemia
|
|
gptkbp:structure
|
type II integral membrane protein
|
|
gptkbp:substrate
|
gptkb:angiotensin_I
gptkb:bradykinin
gptkb:neurotensin
gptkb:enkephalins
gptkb:substance_P
gptkb:vasoactive_intestinal_peptide
gptkb:oxytocin
atrial natriuretic peptide
bombesin
|
|
gptkbp:systematicName
|
metalloendopeptidase
|
|
gptkbp:UniProtID
|
P08473
|
|
gptkbp:bfsParent
|
gptkb:MMP2
|
|
gptkbp:bfsLayer
|
7
|