|
gptkbp:instanceOf
|
gptkb:protein
collagen
|
|
gptkbp:associatedWith
|
sensorineural deafness
ocular abnormalities
hereditary nephritis
|
|
gptkbp:biosynthesisLocation
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:component
|
glomerular basement membrane
lens capsule
epithelial basement membrane
|
|
gptkbp:degradedBy
|
gptkb:matrix_metalloproteinases
|
|
gptkbp:discoveredBy
|
gptkb:Kefalides_NA
|
|
gptkbp:encodedBy
|
gptkb:COL4A2_gene
gptkb:COL4A3_gene
gptkb:COL4A4_gene
gptkb:COL4A5_gene
gptkb:COL4A6_gene
gptkb:COL4A1_gene
|
|
gptkbp:features
|
forms sheet-like networks
interruptions in Gly-X-Y repeats
|
|
gptkbp:foundIn
|
basement membrane
|
|
gptkbp:function
|
structural support
filtration barrier
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
type IV collagen
|
|
gptkbp:molecularWeight
|
~400 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alport_syndrome
gptkb:Goodpasture_syndrome
|
|
gptkbp:postTranslationalModification
|
glycosylation
hydroxylation
|
|
gptkbp:presentIn
|
all metazoans
|
|
gptkbp:requires
|
angiogenesis
cell migration
eye development
cell adhesion
kidney filtration
tissue compartmentalization
|
|
gptkbp:structure
|
triple helix
network-forming collagen
|
|
gptkbp:subunit
|
gptkb:alpha-1(IV)_chain
gptkb:alpha-2(IV)_chain
gptkb:alpha-3(IV)_chain
gptkb:alpha-4(IV)_chain
gptkb:alpha-5(IV)_chain
gptkb:alpha-6(IV)_chain
|
|
gptkbp:bfsParent
|
gptkb:MMP2
gptkb:Nidogen-1
|
|
gptkbp:bfsLayer
|
7
|