|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:abbreviation
|
gptkb:ERK
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
phosphorylation
|
|
gptkbp:alias
|
gptkb:ERK1/2
p44/42 MAPK
|
|
gptkbp:discoveredBy
|
Meloche S.
|
|
gptkbp:EC_number
|
2.7.11.24
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:fullName
|
Mitogen-Activated Protein Kinase (Extracellular signal-Regulated Kinase)
|
|
gptkbp:function
|
signal transduction
response to growth factors
regulation of mitosis
|
|
gptkbp:gene
|
gptkb:MAPK1
gptkb:MAPK3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK (ERK)
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
cell survival
cell signaling
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
16p11.2 (MAPK3)
22q11.22 (MAPK1)
|
|
gptkbp:memberOf
|
gptkb:MAPK_family
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:yeast
right
|
|
gptkbp:pathway
|
gptkb:Ras-Raf-MEK-ERK_pathway
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
|
|
gptkbp:regulates
|
apoptosis
gene expression
cell cycle
|
|
gptkbp:relatedTo
|
gptkb:JNK
gptkb:MAPK_p38
|
|
gptkbp:significance
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:structure
|
serine/threonine kinase
|
|
gptkbp:subspecies
|
gptkb:ERK1
gptkb:ERK2
|
|
gptkbp:UniProtID
|
gptkb:P27361
gptkb:P28482
|
|
gptkbp:bfsParent
|
gptkb:MAP_kinase_kinase_(MEK)
|
|
gptkbp:bfsLayer
|
7
|