|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
environmental stress
pro-inflammatory cytokines
|
|
gptkbp:alternativeName
|
gptkb:p38_MAPK
gptkb:Mitogen-activated_protein_kinase_14
gptkb:p38α
|
|
gptkbp:biologicalProcess
|
signal transduction
immune response
ATP binding
MAPK cascade
protein serine/threonine kinase activity
response to heat
response to cytokine
response to UV
response to lipopolysaccharide
response to osmotic stress
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:MAPK14_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:hasIsoform
|
gptkb:p38α
gptkb:p38β
gptkb:p38γ
gptkb:p38δ
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPK p38
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
inflammatory response
cellular response to stress
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.31
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:serine/threonine_kinase_family
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:HSP27
gptkb:MAPKAPK2
gptkb:STAT1
gptkb:p53
transcription factors
|
|
gptkbp:regulates
|
cell survival
gene expression
cell cycle
cytokine production
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:SB203580
gptkb:BIRB_796
gptkb:VX-702
|
|
gptkbp:UniProtID
|
gptkb:Q16539
|
|
gptkbp:bfsParent
|
gptkb:p38_mitogen-activated_protein_kinases
|
|
gptkbp:bfsLayer
|
7
|