|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:alsoKnownAs
|
gptkb:ERK1
gptkb:Mitogen-activated_protein_kinase_3
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:MAPK3_gene
|
|
gptkbp:Entrez_Gene_ID
|
5595
ENSG00000102882
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:form
|
phosphorylated dimer
|
|
gptkbp:function
|
signal transduction
regulation of cell proliferation
regulation of transcription
regulation of differentiation
regulation of development
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mapk3
|
|
gptkbp:inhibitedBy
|
gptkb:PD98059
gptkb:U0126
gptkb:FR180204
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
cellular response to growth factors
cellular response to stress
cellular response to cytokines
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:ERK_subfamily
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Mapk3
|
|
gptkbp:PDB
|
2ZOQ
|
|
gptkbp:phosphorylates
|
transcription factors
cytoskeletal proteins
Thr202
Tyr204
|
|
gptkbp:regulates
|
apoptosis
differentiation
translator
transcription
cell cycle
|
|
gptkbp:relatedTo
|
gptkb:MAP2K1
gptkb:MAPK1
gptkb:MAP2K2
|
|
gptkbp:structureType
|
serine/threonine kinase
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P27361
|
|
gptkbp:bfsParent
|
gptkb:Extracellular_signal-regulated_kinase
gptkb:MAPK3_gene
|
|
gptkbp:bfsLayer
|
7
|