|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:K-Ras
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:biologicalProcess
|
signal transduction
GTP binding
GTPase activity
cellular response to growth factor stimulus
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:HRAS
gptkb:NRAS
|
|
gptkbp:hasTranscriptVariant
|
2
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRAS2
|
|
gptkbp:involves
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12p12.1
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:mutationAssociatedWith
|
codon 12
codon 13
codon 61
oncogenic mutation
|
|
gptkbp:mutationFrequencyInCancer
|
high
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologIn
|
gptkb:KRAS
|
|
gptkbp:orthologInMouse
|
gptkb:Kras
|
|
gptkbp:product
|
small molecule
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:significance
|
biomarker for targeted therapy
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:targetOfDrug
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:chromosome_12p12.1_(KRAS)
|
|
gptkbp:bfsLayer
|
5
|