|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:KRAS
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
gptkb:KRAS
|
|
gptkbp:hasRefSeqID
|
gptkb:NM_033360
NP_203524
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
K-ras2
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:mutationAssociatedWith
|
codon 12
codon 13
codon 61
oncogenic mutation
|
|
gptkbp:mutationCommonIn
|
gptkb:cancer
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4OBE
5USJ
6OIM
|
|
gptkbp:proteinFamily
|
gptkb:GTP-binding_domain
small molecule
|
|
gptkbp:regulates
|
gptkb:RAF/MEK/ERK_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:target
|
gptkb:adagrasib
gptkb:sotorasib
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:K-Ras
|
|
gptkbp:bfsLayer
|
7
|