|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alternativeName
|
K-Ras 2B
K-RasB
KRAS isoform B
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:determines
|
X-ray crystallography
NMR spectroscopy
|
|
gptkbp:encodedBy
|
gptkb:KRAS_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:hasC-TerminalPolybasicRegion
|
true
|
|
gptkbp:hasCAAXMotif
|
true
|
|
gptkbp:hasEffectorBindingRegion
|
true
|
|
gptkbp:hasFarnesylationSite
|
true
|
|
gptkbp:hasGDomain
|
true
|
|
gptkbp:hasGDPBindingSite
|
true
|
|
gptkbp:hasGTPBindingSite
|
true
|
|
gptkbp:hasHypervariableRegion
|
true
|
|
gptkbp:hasIsoform
|
gptkb:KRAS
|
|
gptkbp:hasNoPalmitoylationSite
|
true
|
|
gptkbp:hasRole
|
oncogenesis
|
|
gptkbp:hasSwitchIIRegion
|
true
|
|
gptkbp:hasSwitchIRegion
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
K-Ras4B
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
cell signaling
|
|
gptkbp:length
|
188 amino acids
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
chromosome 12p12.1
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
small GTPases
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:4OBE
6GJ8
5VQ2
|
|
gptkbp:postTranslationalModification
|
farnesylation
carboxymethylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:target
|
anticancer drug development
|
|
gptkbp:UniProtID
|
gptkb:P01116-2
|
|
gptkbp:bfsParent
|
gptkb:K-Ras
gptkb:K-ras
|
|
gptkbp:bfsLayer
|
7
|