|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:K-Ras
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
|
|
gptkbp:discoveredBy
|
gptkb:Der,_Channing_J.
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
gptkb:KRAS4A
gptkb:KRAS4B
|
|
gptkbp:HGNC_ID
|
6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human KRAS
|
|
gptkbp:interactsWith
|
gptkb:GAPs
gptkb:NF1
gptkb:BRAF
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12p12.1
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
codon 12
codon 13
codon 61
oncogenic mutation
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologInMouse
|
gptkb:Kras
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:product
|
gptkb:KRAS_protein
|
|
gptkbp:proteinFamily
|
gptkb:RAS_family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:RAF/MEK/ERK_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:significance
|
predictive biomarker for targeted therapy
prognostic biomarker
|
|
gptkbp:targetOfDrug
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:Drosophila_Ras85D
|
|
gptkbp:bfsLayer
|
5
|