|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ALK_tyrosine_kinase_receptor
gptkb:CD246
gptkb:NBLST3
|
|
gptkbp:associatedWith
|
gptkb:anaplastic_large_cell_lymphoma
gptkb:neuroblastoma
gptkb:non-small_cell_lung_cancer
|
|
gptkbp:biologicalProcess
|
kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:clinicalTrialPhase
|
gptkb:FISH
gptkb:IHC
gptkb:RT-PCR
|
|
gptkbp:discoveredBy
|
gptkb:Steven_A._Morris
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:anaplastic_lymphoma_kinase
|
|
gptkbp:Entrez_Gene_ID
|
238
ENSG00000171094
|
|
gptkbp:expressedIn
|
gptkb:nervous_system
|
|
gptkbp:fullName
|
gptkb:anaplastic_lymphoma_kinase
|
|
gptkbp:function
|
cell growth regulation
neuronal development
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
427
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ALK
|
|
gptkbp:length
|
1620 amino acids
|
|
gptkbp:locatedOnChromosome
|
2p23.2-p23.1
chromosome 2
|
|
gptkbp:mutationAssociatedWith
|
fusion
point mutation
amplification
|
|
gptkbp:OMIM
|
105590
|
|
gptkbp:orthologInMouse
|
gptkb:Alk
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:phosphorylates
|
Y1278
Y1282
Y1283
|
|
gptkbp:proteinFamily
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:symbol
|
gptkb:ALK
|
|
gptkbp:targetOfDrug
|
gptkb:alectinib
gptkb:brigatinib
gptkb:ceritinib
gptkb:crizotinib
gptkb:lorlatinib
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
gptkb:Q9UM73
|
|
gptkbp:bfsParent
|
gptkb:Alaska_Airlines
gptkb:SriLankan_Airlines
gptkb:ALK_rearrangement
|
|
gptkbp:bfsLayer
|
5
|