Insulin-like growth factor 1 receptor protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:CD221 gptkb:IGF1R
gptkbp:associatedWith	gptkb:cancer growth disorders
gptkbp:biologicalProcess	receptor tyrosine kinase activity
gptkbp:cellularComponent	gptkb:plasma_membrane
gptkbp:discoveredBy	Shiu et al.
gptkbp:discoveredIn	1980
gptkbp:encodedBy	gptkb:IGF1R_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000140443 3480
gptkbp:expressedIn	many tissues
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	regulates cell differentiation regulates cell survival regulates cell growth mediates effects of IGF-1
gptkbp:HGNC_ID	5465
https://www.w3.org/2000/01/rdf-schema#label	Insulin-like growth factor 1 receptor protein
gptkbp:interactsWith	gptkb:SHC1 gptkb:insulin_receptor gptkb:PI3K gptkb:IRS1 GRB10
gptkbp:length	1367 amino acids
gptkbp:ligand	gptkb:insulin-like_growth_factor_2 gptkb:insulin-like_growth_factor_1
gptkbp:locatedOnChromosome	chromosome 15q26.3
gptkbp:molecularWeight	155 kDa (precursor)
gptkbp:mutationAssociatedWith	insulin resistance growth retardation
gptkbp:OMIM	147370
gptkbp:pathway	gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway
gptkbp:PDB	5U8R
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:RefSeq	gptkb:NM_000875
gptkbp:requires	embryonic development
gptkbp:structure	heterotetramer
gptkbp:subunit	alpha subunit beta subunit
gptkbp:target	therapeutic antibodies small molecule inhibitors
gptkbp:UniProtID	gptkb:P08069
gptkbp:bfsParent	gptkb:IGF1R
gptkbp:bfsLayer	8