|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD221
gptkb:Insulin-like_growth_factor_1_receptor
|
|
gptkbp:associatedWith
|
gptkb:cancer
growth regulation
growth retardation
|
|
gptkbp:encodes
|
gptkb:insulin-like_growth_factor_1_receptor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000140443
3480
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
receptor tyrosine kinase activity
mediates IGF1 signaling
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
5465
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF1R gene
|
|
gptkbp:interactsWith
|
gptkb:insulin-like_growth_factor_2
gptkb:insulin_receptor
gptkb:insulin-like_growth_factor_1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
15q26.3
|
|
gptkbp:mutationAssociatedWith
|
insulin resistance
intrauterine growth restriction
|
|
gptkbp:OMIM
|
147370
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Igf1r
|
|
gptkbp:product
|
IGF1R protein
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:target
|
therapeutic antibodies
small molecule inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P08069
|
|
gptkbp:bfsParent
|
gptkb:IGF1_receptor
gptkb:IGF-1R
|
|
gptkbp:bfsLayer
|
7
|